CUR Series Torrent Bioreactor

As a disposable bioreactor developed by JYSS BIO independently, CUR series torrent bioreactor adopts the principle of non-bubbling interface oxygen transfer mechanism for mixing. At the same time of satisfying the needs of large volume production, its advanced mass transfer mode could avoid cell damage caused by the bubble surface tension and high shear force from stirring impellers of bioreactors with other culture methods. In the normal rotation speed range, the mean shear rate of the fluid inside the reactor may be lower than 20S-1, so it's possible to realize the high-density and high-viability culture of cells that are sensitive to the shearing force.

Based on the cell culture demands, CUR series torrent bioreactor has been scaled up in volume and process. It may offer 2.5L-2000L working space (working volume), which could be extensively applied in fields including cell therapy, gene therapy, monoclonal antibody and vaccine.

Features and Advantages

  • Non-bubbling interface oxygen transfer mechanism with highoxygen transfer efficiency
  • No impeller or bottom vent, no need to add defoaming agent
  • Low shearing force, no need to consider the addition of antishear factors
  • Inverted truncated conical tank that has big surface area of air-fluid interface, and stable flow field
  • Scale-up with Froude number Fr brings about good process scale-up reproducibility
  • Easy to culture cells at high density and high viability 
  • Smart control system, simple operation interface
  • Available for local online monitoring of key data (including pH, DO, temperature and rotation speed), real-time acquisition of all data, and generation of reports and curves
  • Remote monitoring of parameter and process, and offering of electronic records and electronic signatures according to FDA 21 CFR part 11s
  • Short delivery time, and 100% consumables integrity testing
  • Adopting fixed specifications; customizable pipelines, accessories and film materials

Application

Cell suspension cultivation

CUR Series Torrent Bioreactor

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